![]() When each intervention was compared with the other, both selective digestive decontamination and selective oropharyngeal decontamination were superior to chlorhexidine. Chlorhexidine was associated with increased mortality (odds ratio 1.25, 1.05 to 1.50). ![]() The direct evidence odds ratio for selective oropharyngeal decontamination was 0.85 (0.74 to 0.97). Results Selective digestive decontamination had a favourable effect on mortality, with a direct evidence odds ratio of 0.73 (95% confidence interval 0.64 to 0.84). Inclusion criteria Prospective randomised controlled trials that recruited adult patients in general intensive care units and studied selective digestive decontamination, selective oropharyngeal decontamination, or oropharyngeal chlorhexidine compared with standard care or placebo. We used pairwise meta-analyses to estimate direct evidence from intervention-control trials and a network meta-analysis within a Bayesian framework to combine direct and indirect evidence. Previous meta-analyses, conference abstracts, and key journals were also searched. ![]() Medline, Embase, and CENTRAL were searched to December 2012. Objectives To determine the effect on mortality of selective digestive decontamination, selective oropharyngeal decontamination, and topical oropharyngeal chlorhexidine in adult patients in general intensive care units and to compare these interventions with each other in a network meta-analysis.ĭesign Systematic review, conventional meta-analysis, and network meta-analysis.
0 Comments
Leave a Reply. |